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- Title
Base‐Mediated Radio‐Iodination of Arenes by Using Organosilane and Organogermane as Radiolabelling Precursors.
- Authors
Bloux, Hugo; Dahiya, Amit; Hébert, Alexandra; Fabis, Frédéric; Schoenebeck, Franziska; Cailly, Thomas
- Abstract
The radio‐iodination of arenes is investigated from organosilane and organogermane precursors using ipso‐electrophilic halogenation (IEH). Discovery of a mild base mediated process allows radio‐iodination in HFIP (1,1,1,3,3,3‐hexafluoro‐2‐propanol) of either aryl silane or germane, with germanes being more reactive. Clinical potential of arylgermanes as radio‐iodination precursors is demonstrated through the labelling of [125I]IMTO (iodometomidate) and [125I]MIBG (meta‐iodobenzylguanidine) thus offering an alternative to radio‐iododestannylation processes using non‐toxic precursors.
- Subjects
RADIOLABELING; AROMATIC compounds; HALOGENATION; RADIOCHEMISTRY; SILANE compounds
- Publication
Chemistry - A European Journal, 2023, Vol 29, Issue 19, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202203366