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- Title
Organization of theMASP2locus and its expression profile in mouse and rat.
- Authors
Stover, Cordula M.; Lynch, Nicholas J.; Hanson, Steven J.; Windbichler, Michaela; Gregory, Simon G.; Schwaeble, Wilhelm J.
- Abstract
The mouse, rat, and human MASP2 loci are situated on syntenic chromosome regions and are highly conserved. They comprise the genes for MASP-2/ MAp 19, TAR DNA binding protein of 43 kDa, FRAP kinase, CDT6, Polymyositis-s cleroderma 100-kDa autoantigen, spermidine synthase, and TERE which were analyzed by annotation of available gene transcript data and cross-species comparison of available genomic sequences. The human and rat genes for spermidine synthase have an additional intron compared to the mouse gene. The mouse and rat genes for Polymyositis-scieroderma 100-kDa auto-antigen have an additional exon compared to the human gene. We find support for the hypothesis that the MAp 19-specific exon within the MASP2 gene may have originated in a transposable element. Blocks of highly conserved intronic sequences were found in the MASP2 gene and the TARDBP gene. The expression of all genes within the MASP2 locus was analyzed in mouse and rat. The restricted expression of MASP-2 and MAp19 mRNA in liver contrasts with the ubiquitous expression of all neighboring genes studied.
- Subjects
POLYMYOSITIS; GENETICS; BIOGENIC amines; SPERMIDINE; DEOXYRIBOSE; DNA
- Publication
Mammalian Genome, 2004, Vol 15, Issue 11, p887
- ISSN
0938-8990
- Publication type
Article
- DOI
10.1007/s00335-004-3006-8