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- Title
Antimicrobial potential of alkalophilic micromycetes Emericellopsis alkalina.
- Authors
Baranova, A.; Georgieva, M.; Bilanenko, E.; Andreev, Ya.; Rogozhin, E.; Sadykova, V.
- Abstract
The ability of alkalophilic micromycetes of the Emericellopsis alkalinа to produce antimicrobial peptides has been studied. Evaluation of the spectrum and the yield of antibiotic compounds has allowed us to choose a promising producer of peptide antimycotics, Emericellopsis аlkalinа А118. The producer exhibits antifungal activity against conditionally pathogenic yeast and mold fungi, i.e., Candida аlbicans, Aspergillus niger, and A. fumigatus. The group of homologous active compounds isolated by the set of identified structural features (molecular weight, the ratio of the absorption at certain wavelengths, and the absence of initiation of Edman sequencing) may be attributed to peptaibols, which are a group of nonribosomal membrane-active antimicrobial peptides with a specificity of action primarily against fungi-micromycetes.
- Subjects
ALKALOPHILIC microorganisms; PEPTIDE antibiotics; ANTI-infective agents; MICROFUNGI; ANTIBACTERIAL agents
- Publication
Applied Biochemistry & Microbiology, 2017, Vol 53, Issue 6, p703
- ISSN
0003-6838
- Publication type
Article
- DOI
10.1134/S0003683817060035