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- Title
侧链衍生季铵盐型氯胺的合成及抗菌应用.
- Authors
李令东; 张颂伟; 张维伦; 刘鹏飞; 于江际鸣; 周 豪
- Abstract
A series of side-chain derived quaternary ammonium (QA) N-chloramines (10-14) were designed and synthesized using commercial 5, 5-dimethylhydantoin (DMH) as raw matesial, and the structures of precursors and corresponding N-chloramines were characterized. The antibacterial activity of chloramines 10-14 was preliminarily tested using Escherichia coli (E.coli) and Staphylococcus aureus (S.aureus) as model strains, and N-chloramine 1 as control. The results showed that antibacterial ability of 10-13 increased and then declined with the length of side chain increased. Namely, tributyl QA N-chloramine 12 with KL of 1. 07±0. 09 and 6. 49 against S.aureus and E.coli, exhibited relatively higher antibacterial efficacy, possibly due to the preferable hydrophilic-lipophilic characteristic required for efficient contact killing. Furthermore, hydroxyethyl counterpart 14 achieved total killing of S.aureus and E.coli, demonstrating the towering antibacterial capability among N-chloramines 10-14, which may be attributed to its facile transportation across bacterial cell membrane. The series of efficacious N-chloramine disinfectants prepared in this work provide reference for the development of more efficient ionic N-chloramine antibacterial agents.
- Subjects
BACTERIAL cell membranes; TREATMENT effectiveness; ANTIBACTERIAL agents; STAPHYLOCOCCUS aureus; ESCHERICHIA coli
- Publication
Chinese Journal of Applied Chemistry, 2024, Vol 41, Issue 7, p966
- ISSN
1000-0518
- Publication type
Article
- DOI
10.19894/j.issn.1000-0518.230394