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- Title
Molecular networks as sensors and drivers of common human diseases.
- Authors
Schadt, Eric E.
- Abstract
The molecular biology revolution led to an intense focus on the study of interactions between DNA, RNA and protein biosynthesis in order to develop a more comprehensive understanding of the cell. One consequence of this focus was a reduced attention to whole-system physiology, making it difficult to link molecular biology to clinical medicine. Equipped with the tools emerging from the genomics revolution, we are now in a position to link molecular states to physiological ones through the reverse engineering of molecular networks that sense DNA and environmental perturbations and, as a result, drive variations in physiological states associated with disease.
- Subjects
MOLECULAR biology; DISEASES; DNA; RNA; PROTEIN synthesis; GENOMICS; REVERSE engineering; ECOLOGICAL disturbances; CLINICAL medicine
- Publication
Nature, 2009, Vol 461, Issue 7261, p218
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature08454