We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recent progress in vaccine development targeting pre-clinical human toxoplasmosis.
- Authors
Ki-Back Chu; Fu-Shi Quan
- Abstract
Toxoplasma gondii is an intracellular parasitic organism affecting all warm-blooded vertebrates. Due to the unavailability of commercialized human T. gondii vaccine, many studies have been reported investigating the protective efficacy of pre-clinical T. gondii vaccines expressing diverse antigens. Careful antigen selection and implementing multifarious immunization strategies could enhance protection against toxoplasmosis in animal models. Although none of the available vaccines could remove the tissue-dwelling parasites from the host organism, findings from these pre-clinical toxoplasmosis vaccine studies highlighted their developmental potential and provided insights into rational vaccine design. We herein explored the progress of T. gondii vaccine development using DNA, protein subunit, and virus-like particle vaccine platforms. Specifically, we summarized the findings from the pre-clinical toxoplasmosis vaccine studies involving T. gondii challenge infection in mice published in the past 5 years.
- Subjects
VACCINE development; TOXOPLASMA gondii; VIRUS-like particles; NUCLEOTIDE sequence; IMMUNIZATION
- Publication
Parasites, Hosts & Diseases, 2023, Vol 61, Issue 3, p231
- ISSN
2982-5164
- Publication type
Article
- DOI
10.3347/PHD.22097