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- Title
Organelle biogenesis: A (nu)clear picture of envelope assembly.
- Authors
Pickett, James
- Abstract
The article discusses a study by Anderson and Hetzer which shows that the nuclear envelope (NE) is derived from the endoplasmic reticulum (ER). The researchers also propose a mechanism for NE assembly based on protein-DNA interactions. They conclude that the ER is the major source of NE membranes and that by harnessing DNA-protein interactions and the dynamic shape-changing capabilities of the ER, NE assembly can occur without the need for adenosine triphosphate (ATP) or vesicle trafficking.
- Subjects
NUCLEAR membranes; ENDOPLASMIC reticulum; DNA-protein interactions; PROTEIN binding; ORGANELLES; CELL membranes; ADENOSINE triphosphate
- Publication
Nature Reviews Molecular Cell Biology, 2007, Vol 8, Issue 10, p756
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2266