We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insights into RNA structure and function from genome-wide studies.
- Authors
Mortimer, Stefanie A.; Kidwell, Mary Anne; Doudna, Jennifer A.
- Abstract
A comprehensive understanding of RNA structure will provide fundamental insights into the cellular function of both coding and non-coding RNAs. Although many RNA structures have been analysed by traditional biophysical and biochemical methods, the low-throughput nature of these approaches has prevented investigation of the vast majority of cellular transcripts. Triggered by advances in sequencing technology, genome-wide approaches for probing the transcriptome are beginning to reveal how RNA structure affects each step of protein expression and RNA stability. In this Review, we discuss the emerging relationships between RNA structure and the regulation of gene expression.
- Subjects
MOLECULAR structure of RNA; GENOMES; PROTEIN expression; GENE expression; CELL physiology
- Publication
Nature Reviews Genetics, 2014, Vol 15, Issue 7, p469
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg3681