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- Title
A Novel Approach on Micro Sponges Drug Delivery System: Method of Preparations, Application, and its Future Prospective.
- Authors
Mandal, Suraj; Bhumika, Km.; Kumar, Mukesh; Hak, Jiyaul; Vishvakarma, Prabhakar; Sharma, Umesh Kumar
- Abstract
Microsponges are porous microspheres ranging in size from 5 to 300 micrometers used in a polymeric delivery system. They have been studied for biomedical applications, including targeted medicine delivery, transdermal drug delivery, anticancer drug delivery, and bone substitutes. This research aims to conduct a detailed examination of existing trends and future prospects for a microsponge-based medicine delivery system. The current study investigates the Microsponge Delivery System's design, operation, and possible therapeutic uses (MDS). The therapeutic potential of microsponge-based formulations, as well as patent data, were thoroughly investigated. The authors discuss several efficient methods for producing microsponges, including liquid-liquid suspension polymerization, quasi-emulsion solvent diffusion, water-in-oil-in-water (w/o/w) emulsion solvent diffusion, oil-in-oil emulsion solvent diffusion, the lyophilization method, the porogen addition method, the vibrating orifice aerosol generator method, the electrohydrodynamic atomization method, and the ultrasound-assisted microsponge. Microsponge may reduce undesired side effects and increase drug stability by boosting drug release. Hydrophilic and hydrophobic drugs can be loaded into a microsponge and transported to a specific target. When compared to traditional distribution methods, microsponge delivery technology offers numerous advantages. Microsponges, which are spherical, sponge-like nanoparticles with porous surfaces, can help increase drug stability. They efficiently alter drug release while also reducing adverse effects.
- Subjects
DRUG delivery systems; TRANSDERMAL medication; CIRCULAR RNA; DRUG stability; BONE substitutes
- Publication
Indian Journal of Pharmaceutical Education & Research, 2024, Vol 58, Issue 1, p45
- ISSN
0019-5464
- Publication type
Article
- DOI
10.5530/ijper.58.1.5