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- Title
Premarital Screening Program for Hemoglobinopathies in Karbala, Iraq.
- Authors
Attiyah, Mohammed N.; Al-Najafi, Waleed K.
- Abstract
Background: Premarital screening program for hemoglobinopathies started in Karbala governorate on June13, 2012. Aim: To evaluate the premarital screening program in Karbala governorate. Methods: A cross-sectional study by reviewing the records of five premarital clinics and Karbala hereditary blood disease center from first of March 2016 to first of October 2018. Total number of individuals screened for hemoglobinopathies were 52014 (26007 couples). Complete blood count (CBC) was done for all screened couples. If both man and woman have mean corpuscular volume (MCV) < 80 femto liter (fl) and/or mean corpuscular hemoglobin (MCH) < 27 picogram (pg) they should be referred to Karbala hereditary blood diseases center for further investigation of abnormal hemoglobin. Prevalence of abnormal hemoglobin calculated by Punnett Square equation and Hardy-Weinberg law. Results: Number of individuals referred from peripheral premarital clinics to the center were 1780 (890 couples). Individuals included in the study were1560 (87.7%) from Karbala governorate, the rest with missing address or from other governorates were excluded. The most prevalent hemoglobinopathy among referred individuals was B-thalassemia 344(22.05%). Referred individuals with sickle hemoglobin were 51(3.26%). Prevalence of B-thalassemia and sickle hemoglobin in this study was 3.8% (95% confidence interval (CI) 3.64 - 3.96) and 0.56% (95% CI 0.5 - 0.62), respectively. High-risk marriage couples were 84 (3.2/1000). Conclusion: The premarital screening for hemoglobinopathies program in Karbala governorate was able to detect many risky marriages although it still needs more improvement.
- Subjects
KARBALA (Iraq); HEMOGLOBIN polymorphisms; BLOOD cell count; BLOOD diseases; HEMOGLOBINOPATHY; HARDY-Weinberg formula
- Publication
Kerbala Jorunal of Medicine, 2020, Vol 13, Issue 1, p2293
- ISSN
1990-5483
- Publication type
Article