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- Title
The Role of Macromolecular Damage in Aging and Age-related Disease.
- Authors
Richardson, Arlan G.; Schadt, Eric E.
- Abstract
Several decades of research have shown that macromolecular damage increases with age and that damage to protein, DNA, lipids, and other macromolecular components appears to be important factors in specific age-related diseases. The strongest evidence that macromolecular damage is a causative factor in aging comes from studies using manipulations that increase life span. However, it is currently unclear whether damage to macromolecules plays a role in the actual processes of aging. In other words, is macromolecular damage driven by aging or is it that damage to a key molecular component directly causes aging?
- Subjects
AGING; PHYSIOLOGICAL aspects of aging; OXIDATIVE stress; OXIDATION-reduction reaction; PHYSIOLOGICAL stress; MACROMOLECULAR dynamics
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2014, Vol 69, Issue Suppl_1, pS28
- ISSN
1079-5006
- Publication type
Article
- DOI
10.1093/gerona/glu056