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- Title
P-148: Genetic involvement of T+31C polymorphism in angiotensinogen gene for daytime and nighttime blood pressure: The O study.
- Authors
Sugimoto, Ken; Mikami, Tadayoshi; Katsuya, Tomohiro; Ohkubo, Takayoshi; Hozawa, Atsushi; Fukuda, Masayuki; Matsubara, Mitsunobu; Tsuji, Ichiro; Araki, Tsutomu; Satoh, Hiroshi; Higaki, Jitsuo; Hisamichi, Shigeru; Imai, Yutaka; Ogihara, Toshio
- Abstract
Objectives: The polymorphisms of human angiotensinogen gene were reported as genetic predisposing factors for cardiovascular disease. We recently documented that T+31C polymorphism in intron 1 of angiotensinogen gene (T+31C/AGT) was associated with the presence of family history of hypertension. We performed an association study using the participants of the O Study to assess the precise correlation between T+31C/AGT and blood pressure(BP).Method: Subjects(n=1,744) were enlisted from O population, which is a cohort in a rural community in northern Japan. In addition to the casual BP measurement, home BP measurements and 24hr ambulatory BP monitoring were obtained from the participants. After obtaining the informed consent for genetic analysis, T+31C/AGT was determined by TaqMan PCR method, which is a powerful tool for semiautomatic genotype determination without gel electrophoresis.Results: T+31C/AGT was not associated with any kind of BP values (casual BP, home BP and mean value of 24hr, daytime and nighttime BP). However, the frequency of non-dipper was higher in subjects with CC genotype (21.5%) (=TT genotype for M235T polymorphism) than those with T+31 allele (16.9%).Conclusion: The increase of non-dipper in the carrier of CC genotype was one of the reasons suggesting the genetic involvement of AGT polymorphism in the risk for cardiovascular disease.Am J Hypertens (2001) 14, 79A-80A; doi:S0895-7061(01)01757-5
- Publication
American Journal of Hypertension, 2001, Vol 14, p79A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)01757-5