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- Title
P-260: Effect of anti-hypertensive agents on plasma fibrinogen levels in patients with essential hypertension.
- Authors
Papadakis, John A.; Vrentzos, George; Perisinaki, Garyfalia; Kalikaki, Adonia; Ganotakis, Emmanouel S.
- Abstract
In addition to hypertension, dyslipidaemia and smoking, elevated plasma levels of fibrinogen (Fib) have also been associated with increased risk of cardiovascular (CVD) events. We investigated the influence of anti-hypertensive treatment on this CVD predictor in 427 patients (177 men) with essential hypertension.Their median age was 60 (range: 18 to 87) years. Of the hypertensive patients, 259 (60.7%) were receiving anti-hypertensive agents. Of the treated hypertensives, 135 patients (52.1%) were under one, 93 (35.9%) under two, 25 (9.7%) under three and 6 (2.3%) under four anti-hypertensive drugs. Only 57 (22.0%) out of 259 treated hypertensives were well controlled (blood pressure levels bellow 140/90mmHg).Anti-hypertensive drug use was associated with significantly lower plasma Fib concentration when compared with untreated hypertensives [median values (range): 250 (170-400) vs 300 (170-540) mg/dl, respectively; p<0.01, Mann-Whitney test]. There were no significant differences in serum levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides between these two groups of hypertensives.In conclusion: In addition to lowering arterial blood pressure, anti-hypertensive agents may also decrease plasma levels of Fib, another modifiable cardiovascular risk factor.Am J Hypertens (2001) 14, 116A-116A; doi:S0895-7061(01)02114-8
- Publication
American Journal of Hypertension, 2001, Vol 14, p116A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)02114-8