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- Title
Hand knob sign in Marchiafava–Bignami disease and Wernicke's encephalopathy.
- Authors
Hiraga, Akiyuki
- Abstract
The letter discusses a recent NeuroImage article that explores the hand knob area abnormalities in Marchiafava-Bignami disease (MBD) and Wernicke's encephalopathy (WE). MBD is a condition characterized by toxic demyelination and necrosis, primarily affecting the corpus callosum. In contrast, WE typically involves specific regions of the brain with high thiamine content and turnover. While cortical involvement in MBD and WE cases is rare, some cases have shown abnormalities in the hand knob area on MRI. The underlying pathophysiology of cortical involvement in WE is not yet understood, but it may be related to the high demand for glucose and thiamine in the hand knob area or increased lactate levels caused by thiamine deficiency. The letter emphasizes the importance of paying attention to cortical abnormalities in MBD and corpus callosum abnormalities in WE.
- Subjects
WERNICKE'S encephalopathy; BLOOD lactate; VITAMIN B deficiency; CORPUS callosum
- Publication
Neurological Sciences, 2024, Vol 45, Issue 6, p2903
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-024-07345-7