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- Title
Association of serum levels of intercellular adhesion molecule-1 and interleukin-6 with migraine.
- Authors
Wang, Fengzhi; He, Qiu; Ren, Zhanxiu; Li, Fuyong; Chen, Wei; Lin, Xiang; Zhang, Hemin; Tai, Guofeng
- Abstract
To investigate the associations of serum levels of intercellular adhesion molecule-1 (ICAM1) and the pro-inflammatory cytokine interleukin-6 (IL-6) with migraine and migraine subtypes, and to study their correlation with each other in this condition. We used enzyme-linked immunosorbent assay to measure serum levels of ICAM1 and IL-6 in 103 migraine patients with and without aura, in both attack and pain-free periods, and in 100 healthy control subjects. Serum levels of ICAM1 and IL-6 were significantly higher in migraine patients during attacks than in controls ( p < 0.05). Serum ICAM1 levels were significantly higher in migraine with aura (MA) than in migraine without aura (MO), ( p < 0.05). Correlation analysis indicated a significant positive correlation between serum levels of ICAM1 and IL-6 ( p < 0.05) in migraine patients during attacks. Our results indicate that ICAM1 and IL-6 are involved in the pathogenesis of migraine attacks, possibly via an interactive mechanism.
- Subjects
SERUM; CD54 antigen; INTERLEUKIN-6; MIGRAINE; CYTOKINES; ENZYME-linked immunosorbent assay; INFLAMMATION
- Publication
Neurological Sciences, 2015, Vol 36, Issue 4, p535
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-014-2010-3