We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Euphocactoside, a New Megastigmane Glycoside from Euphorbia cactus Growing in Saudi Arabia.
- Authors
Aati, Hanan Y.; Perveen, Shagufta; Al-Qahtani, Jawaher; Peng, Jiangnan; Al-Taweel, Areej; Alqahtani, Ali S.; ElGamal, Ali; Chianese, Giuseppina; Nasr, Fahd A.; Taglialatela-Scafati, Orazio; Parvez, Mohammad K.
- Abstract
A phytochemical investigation of the aerial parts of Euphorbia cactus Ehrenb. ex Boiss. revealed a new megastigmane, euphocactoside (5), along with eleven known metabolites. Euphocactoside (5) is the 3-O-glucoside derivative of a polyhydroxylated megastigmane showing unprecedented structural features. The structure of euphocactoside, including stereochemical details, was elucidated by extensive spectroscopic analysis based on 1D and 2D nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HR-ESIMS). The isolated compounds were evaluated for their cytotoxic activity against three different human cancer cell lines, namely, A549 (lung), LoVo (colon), and MCF-7 (breast), using MTT assay, and moderate to marginal activities were observed for compounds 1–3, 8 and 9 against all three cell lines.
- Subjects
SAUDI Arabia; EUPHORBIA; CACTUS; NUCLEAR magnetic resonance; MASS spectrometry; CELL lines
- Publication
Plants (2223-7747), 2022, Vol 11, Issue 6, p811
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants11060811