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- Title
Assessment of PGT-A Outcomes Based on Indications for IVF Treatment.
- Authors
YAĞIBASAN, Ege; ÖZCAN, Pınar; TİMUR, Hikmet Tunç; TANOĞLU, Fatma Başak; PASİN, Özge
- Abstract
Introduction: There are multiple reasons to consider preimplantation genetic testing for aneuploidy (PGT-A) for women undergoing in vitro fertilization (IVF) treatment. Different indications are anticipated to identify a greater number of aneuploidies than others. Our objective was to assess PGT-A results according to indications regarding the likelihood of identifying aneuploidy. Method: This retrospective cohort study in a single center was conducted at the IVF center of Bezmialem University Hospital. We analyzed PGT-A results of 446 blasts that underwent PGT-A due to the following indications: advanced maternal age, history of recurrent spontaneous abortion, history of recurrent implantation failure, serious male factor, poor embryo quality, or a combination of two or more of these factors. Next-generation sequencing was used for the PGT-A analysis. Results: Two thousand and four hundred seven oocytes were retrieved, resulting in the fertilization of 1,300 oocytes. Subsequently, 446 embryos underwent biopsy for PGT-A. The mean ages of the women and men were 34.47±5.83 and 36.5±6.31 respectively. The most common indication for PGT-A was patients with advanced maternal age, accounting for 23.1% of cases; the other indications were as follows: recurrent spontaneous abortion, 20.2%; poor embryo quality, 19.7%; recurrent implantation failure, 15.8%; mixed, 12.3%; and severe male factor, 8.9%. PGT-A analysis indicated that 237 embryos were euploid, while chaotic and aneuploid embryos were 141 and 114 respectively. The rates of euploidy within the indications for PGT-A were 51.1% for advanced maternal age, 82.9% for recurrent spontaneous abortion, 93.8% for recurrent implantation failure, 94.4% for severe male factor, 72.5% for poor embryo quality, and 32% for mixed. Conclusion: PGT-A results reveal that the ratio of euploidy is lower in advanced maternal age than in other indications. Patients who underwent mixed PGT-A had the lowest rate of euploidy.
- Subjects
HUMAN in vitro fertilization; FERTILIZATION in vitro; MATERNAL age; EMBRYO implantation; NUCLEOTIDE sequencing; RECURRENT miscarriage
- Publication
Bezmialem Science, 2024, Vol 13, pS7
- ISSN
2148-2373
- Publication type
Abstract