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- Title
Health related quality of life among persons with HIV after the use of protease inhibitors.
- Authors
Low-Beer, S.; Chan, K.; Wood, E.; Yip, B.; Montaner, J. S. G.; O'Shaughnessy, M. V.; Hogg, R. S.; Montaner, J S
- Abstract
<bold>Objective: </bold>This study was conducted to determine the effect of the use of HIV protease inhibitors on the quality of life among persons infected with HIV.<bold>Methods: </bold>Subjects were participants in the British Columbia Centre for Excellence in HIV/AIDS Drug Treatment Program who had completed two annual participant surveys, one prior to initiating therapy with a protease inhibitor and one after. Quality of life was measured using the Medical Outcomes Study Short Form Health Survey (MOS-SF). Statistical analyses were conducted using parametric and multivariate methods.<bold>Results: </bold>Our analysis was based on 179 HIV-positive individuals. Compared to quality of life at baseline, we found no statistically significant changes in the health perception, pain, physical, role and social functioning MOS-SF subscale scores at follow-up. The measure of mental health was the only component to decline significantly over time. Subanalyses found significant increases in the measures of health perception (p = 0.004), physical (p = 0.037), role (p < 0.001) and social functioning (p = 0.053) for individuals with a low baseline quality of life. For those with a higher quality of life before starting a protease inhibitor containing regimen we observed a significant decline in the subscales of mental health (p = 0.001), physical (p = 0.007), role (p = 0.021) and social functioning (p = 0.003) over the study period.<bold>Conclusions: </bold>Our findings indicate that despite strict dosage requirements and adverse side effects associated with protease inhibitor use patients are on the whole maintaining their quality of life after starting on a protease inhibitor containing regimen. Continued follow-up of this cohort will be required to determine the long term implications of these observations.
- Subjects
CANADA; BRITISH Columbia; HIV infections; AIDS; ENZYME inhibitors; ANTIVIRAL agents; QUALITY of life; HIV protease inhibitors; COMPARATIVE studies; HEALTH status indicators; RESEARCH methodology; MEDICAL cooperation; MULTIVARIATE analysis; NONPARAMETRIC statistics; QUESTIONNAIRES; REGRESSION analysis; RESEARCH; EVALUATION research; THERAPEUTICS
- Publication
Quality of Life Research, 2000, Vol 9, Issue 8, p941
- ISSN
0962-9343
- Publication type
journal article
- DOI
10.1023/A:1008985728271