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- Title
Chronic imaging of cortical sensory map dynamics using a genetically encoded calcium indicator.
- Authors
Minderer, Matthias; Liu, Wenrui; Sumanovski, Lazar T.; Kügler, Sebastian; Helmchen, Fritjof; Margolis, David J.
- Abstract
Non-technical summary Optical imaging is widely used to map functional areas of the cerebral cortex. We present a method for fast fluorescence imaging of map-level cortical activity using a calcium indicator protein. Sensory-evoked neuronal activity can be imaged repeatedly in the same mouse over weeks, enabling new opportunities for the longitudinal study of cortical function and dysfunction. We hope this method will be flexibly applied across different cortical areas and to a variety of newly developed genetically encoded calcium and voltage sensors.
- Subjects
BRAIN imaging; CEREBRAL cortex; IMAGING systems in biology; CALCIUM; PROTEINS; NEURONS; LABORATORY mice
- Publication
Journal of Physiology, 2012, Vol 590, Issue 1, p99
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/jphysiol.2011.219014