We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Determinants of Low Disease Activity and Remission in Pediatric Systemic Lupus Erythematosus Patients.
- Authors
KAPLAN, Melike Mehveş; GÜNGÖRER, Vildan; ÇELİKEL, Elif; TEKİN, Zahide EKİCİ; KURT, Tuba; TEKGÖZ, Nilüfer; SEZER, Müge; KARAGÖL, Cüneyt; COŞKUN, Serkan; ÖNER, Nimet; POLAT, Merve Cansu; ÇAYCI, Fatma Şemsa; ACAR, Banu ÇELİKEL
- Abstract
Objective: In our study, it was aimed to investigate the effects of disease symptoms at presentation in pediatric systemic lupus erythematosus (SLE) patients on low disease activity and remission success after the 2nd year of the disease. Material and Methods: Demographic, clinical, and laboratory data of pediatric SLE patients being followed up at our center were obtained from their electronic medical records and patient files. Disease activity at 2 years after diagnosis was measured based on SLE Disease Activity Index-2000 (SLEDAI-2K) scores. Results: In this study, 29 patients diagnosed with pediatric SLE and followed up regularly for at least 2 years were included. At 2 years following diagnosis, according to their SLE activity measurements, 14 (48.2%) patients had high disease activity status (HDAS), whereas 15 (51.7%) had low disease activity status (LDAS)-remission. There was no statistically significant difference between the initial presenting symptoms of the two groups. At 5 years following diagnosis, among 15 patients, 6 (40%) had LDAS-remission, and 9 (60%) had HDAS. The 5th-year SLEDAI-2K scores of the patients with HDAS at 2 years were significantly higher than the 5th-year scores of those with LDAS-remission at 2 years (p=0.028). It was also found that the HDAS of 8 patients who had active disease at 2 years (80%) continued at 5 years. Conclusion: The results of our study showed that pediatric SLE presenting symptoms did not have a significant determining effect on low disease activity and remission at 2 years. On the other hand, low disease activity and remission observed at 2 years may be indicative of LDAS and remission at 5 years.
- Subjects
DISEASE remission; SYSTEMIC lupus erythematosus
- Publication
Journal of Pediatric Disease / Türkiye Çocuk Hastalıkları Dergisi, 2023, Vol 17, Issue 3, p194
- ISSN
1307-4490
- Publication type
Article
- DOI
10.12956/tchd.1205213