The article offers the author's insights on various ways of addressing troubles in liquid chromatography (LC) applications. The author cites methods and calculations for the proper amount of samples to be injected in an ultrahigh-pressure LC (UHPLC). He suggests the use of the needle-in-loop design of autosampler for determining the correct wash solvent to be used to reduce carryover. He adds ways of determining the purity of reference standards, showed in a chromatogram.