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- Title
The altered right frontoparietal network functional connectivity in migraine and the modulation effect of treatment.
- Authors
Zhengjie Li; Lei Lan; Fang Zeng; Makris, Nikos; Jiwon Hwang; Taipin Guo; Feng Wu; Yujie Gao; Mingkai Dong; Mailan Liu; Jie Yang; Ying Li; Qiyong Gong; Sharon Sun; Fanrong Liang; Jian Kong; Li, Zhengjie; Lan, Lei; Zeng, Fang; Hwang, Jiwon
- Abstract
Aims This study aims to investigate the resting-state functional connectivity (rs-fc) of the right frontoparietal network (rFPN) between migraineurs and healthy controls (HCs) in order to determine how the rFPN rs-fc can be modulated by effective treatment. Methods One hundred patients and 46 matched HCs were recruited. Migraineurs were randomized to verum acupuncture, sham acupuncture, and waiting list groups. Resting-state functional magnetic resonance imaging data were collected before and after longitudinal treatments. Independent component analysis was applied in the data analysis. Results We found that migraineurs showed decreased rs-fc between the rFPN and bilateral precuneus compared with HCs. After treatments (real and sham), rFPN rs-fc with the precuneus was significantly reduced. This reduction was associated with headache intensity relief. In order to explore the role of the precuneus in acupuncture modulation, we performed a seed-based rs-fc analysis using the precuneus as a seed and found that the precuneus rs-fc with the bilateral rostral anterior cingulate cortex/medial prefrontal cortex, ventral striatum, and dorsolateral prefrontal cortex was significantly enhanced after treatment. Conclusion Our results suggest that migraineurs are associated with abnormal rFPN rs-fc. An effective treatment, such as acupuncture, may relieve symptoms by strengthening the cognitive adaptation/coping process. Elucidation of the adaptation/coping mechanisms may open up a new window for migraine management.
- Subjects
MIGRAINE; HEADACHE treatment; NEURAL circuitry; ACUPUNCTURE; CONTROL groups; FUNCTIONAL magnetic resonance imaging; FRONTOPARIETAL network; FUNCTIONAL connectivity; PARIETAL lobe; FRONTAL lobe; RESEARCH; NERVOUS system; RESEARCH methodology; MAGNETIC resonance imaging; EVALUATION research; MEDICAL cooperation; TREATMENT effectiveness; COMPARATIVE studies; RANDOMIZED controlled trials; RESEARCH funding
- Publication
Cephalalgia, 2017, Vol 37, Issue 2, p161
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1177/0333102416641665