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- Title
Analyzing Neck Circumference as an Indicator of CPAP Treatment Response in Obstructive Sleep Apnea with Network Medicine.
- Authors
Mihaicuta, Stefan; Udrescu, Lucreţia; Udrescu, Mihai; Toth, Izabella-Anita; Topîrceanu, Alexandru; Pleavă, Roxana; Ardelean, Carmen
- Abstract
We explored the relationship between obstructive sleep apnea (OSA) patients' anthropometric measures and the CPAP treatment response. To that end, we processed three non-overlapping cohorts ( D 1 , D 2 , D 3 ) with 1046 patients from four sleep laboratories in Western Romania, including 145 subjects ( D 1 ) with one-night CPAP therapy. Using D 1 data, we created a CPAP-response network of patients, and found neck circumference (NC) as the most significant qualitative indicator for apnea–hypopnea index (AHI) improvement. We also investigated a quantitative NC cutoff value for OSA screening on cohorts D 2 (OSA-diagnosed) and D 3 (control), using the area under the curve. As such, we confirmed the correlation between NC and AHI ( ρ = 0.35 , p < 0.001 ) and showed that 71% of diagnosed male subjects had bigger NC values than subjects with no OSA (area under the curve is 0.71, with 95% CI 0.63–0.79, p < 0.001 ); the optimal NC cutoff is 41 cm, with a sensitivity of 0.8099, a specificity of 0.5185, positive predicted value (PPV) = 0.9588, negative predicted value (NPV) = 0.1647, and positive likelihood ratio (LR+) = 1.68. Our NC = 41 cm threshold classified the D 1 patients' CPAP responses—measured as the difference in AHI prior to and after the one-night use of CPAP—with a sensitivity of 0.913 and a specificity of 0.859.
- Subjects
ROMANIA; SLEEP apnea syndromes; NECK
- Publication
Diagnostics (2075-4418), 2021, Vol 11, Issue 1, p86
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics11010086