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- Title
Increased alpha-B-crystallin expression in mammary metaplastic carcinomas.
- Authors
Siu-Ki Chan; Lui, Philip C. W.; Puay-Hoon Tan; Yamaguchi, Rin; Moriya, Takuya; Yu, Alex M. C.; Mu-Min Shao; Thazin Hliang; Sio-In Wong; Tse, Gary M.
- Abstract
Chan S-K, Lui P C W, Tan P-H, Yamaguchi R, Moriya T, Yu A M C, Shao M-M, Hliang T, Wong S-I & Tse G M (2011) Histopathology 59, 247-255 Increased alpha-B-crystallin expression in mammary metaplastic carcinomas Aims: Mammary metaplastic carcinoma is a rare breast carcinoma, and may present diagnostic difficulty. Alpha-B-crystallin has been recently reported to be expressed in basal-like and metaplastic carcinomas. Methods and results: Thirty-three metaplastic carcinomas, 44 conventional high-grade carcinomas and 28 mesenchymal spindle cell neoplasms as controls were assessed for their expression of αB-crystallin and conventional basal-like phenotypic markers CK5/6, CK14, p63, c-kit and epidermal growth factor receptor (EGFR) by immunohistochemistry. Alpha-B-crystallin staining was positive in 68% of the metaplastic carcinomas with cytoplasmic staining in all tumour cell components. CK5/6, CK14, p63, c-kit and EGFR stained 43%, 68%, 45%, 21% and 25% of the metaplastic carcinomas, respectively. Combining these markers, 84% of the metaplastic carcinomas expressed either αB-crystallin or CK14. In comparison, only 14% (six cases) of conventional high-grade carcinoma and 7% (two cases) of mesenchymal spindle cell neoplasm expressed αB-crystallin; all but one of these carcinomas were ER/PR/HER2 triple-negative. Conclusions: Using αB-crystallin for diagnosis of metaplastic carcinoma gives a 68% sensitivity, 88% specificity, 74% positive predictive value, 85% negative predictive value and 78% accuracy. The sensitivity is enhanced to 84% with combinations of αB-crystallin/CK14. Alpha-B-crystallin may be used as an adjunct marker in the diagnosis of metaplastic carcinoma.
- Subjects
BREAST cancer diagnosis; PROGESTERONE receptors; EPIDERMAL growth factor; IMMUNOHISTOCHEMISTRY; TUMOR markers
- Publication
Histopathology, 2011, Vol 59, Issue 2, p247
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/j.1365-2559.2011.03882.x