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- Title
Preventive effect of levodopa on vitiligo development: a nationwide case–control study.
- Authors
Bae, Jung Min; Kim, Miri; Han, Ju Hee; Lee, Solam; Ju, Hyun Jeong; Kim, Jee Woo; Almurayshid, Abdurrahman; Choi, Chong Won
- Abstract
Although the incidence of levodopa-induced cutaneous adverse reactions has not been fully evaluated, recent studies have revealed that melanocyte-associated skin adverse reaction is the most common.1 Cases of darkening of white hair following levodopa therapy for Parkinson disease have been reported.2 Notably, I in vitro i studies have revealed the protective effect of levodopa on neuronal cells.3 Therefore, we speculated that levodopa may exert a protective effect on melanocytes and could prevent vitiligo development. Dear Editor, Levodopa, an amino acid precursor of dopamine and melanin, has been widely used to treat patients with Parkinson disease. Levodopa-induced skin disorders in patients with Parkinson disease: a systematic literature review approach.
- Subjects
VITILIGO; DOPA; CASE-control method
- Publication
British Journal of Dermatology, 2022, Vol 187, Issue 2, p259
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/bjd.21054