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- Title
A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target.
- Authors
Nakamura, Satoshi; Takemori, Mihiro; Nakaichi, Tetsu; Shuto, Yasunori; Kashihara, Tairo; Iijima, Kotaro; Chiba, Takahito; Nakayama, Hiroki; Urago, Yuka; Nishina, Shuka; Kobayashi, Yuta; Kishida, Hironori; Imamichi, Shoji; Takahashi, Kana; Masutani, Mitsuko; Okamoto, Hiroyuki; Nishio, Teiji; Itami, Jun; Igaki, Hiroshi
- Abstract
Accelerator-based boron neutron capture therapy (BNCT) systems employing a solid-state lithium target indicated the reduction of neutron flux over the lifetime of a target, and its reduction could represent the neutron flux model. This study proposes a novel compensatory approach for delivering the required neutron fluence and validates its clinical applicability. The proposed approach relies on the neutron flux model and the cumulative sum of real-time measurements of proton charges. The accuracy of delivering the required neutron fluence for BNCT using the proposed approach was examined in five Li targets. With the proposed approach, the required neutron fluence could be delivered within 3.0%, and within 1.0% in most cases. However, those without using the proposed approach exceeded 3.0% in some cases. The proposed approach can consider the neutron flux reduction adequately and decrease the effect of uncertainty in neutron measurements. Therefore, the proposed approach can improve the accuracy of delivering the required fluence for BNCT even if a neutron flux reduction is expected during treatment and over the lifetime of the Li target. Additionally, by adequately revising the approach, it may apply to other type of BNCT systems employing a Li target, furthering research in this direction.
- Subjects
BORON-neutron capture therapy; NEUTRON flux; NEUTRON generators; NEUTRON measurement; NEUTRONS; LITHIUM carbonate
- Publication
Scientific Reports, 2024, Vol 14, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-024-62060-9