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- Title
The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.
- Authors
Wu, G. Q.; Zhao, Y. M.; Lai, X. Y.; Luo, Y.; Tan, Y. M.; Shi, J. M.; Li, L.; Zheng, W. Y.; Zhang, J.; Hu, X. R.; Jin, A. Y.; He, J. S.; Xie, W. Z.; Ye, X. J.; Cai, Z.; Lin, M. F.; Huang, H.
- Abstract
The effect of natural killer (NK) cell alloreactivity on the outcome of unrelated hematopoietic SCT (HSCT) remains a topic of debate. NK cell alloreactivity after allogeneic HSCT is regulated by killer-cell Ig-like receptors (KIRs). To investigate the influence of KIRs on outcome after unrelated HSCT, we retrospectively analyzed the HLA and KIR genotypes of 116 donor-recipient pairs. We found that missing KIR ligands in recipients were significantly associated with a decreased leukemic relapse risk (P=0.019, HR=0.329), mainly in myeloid disease (P=0.003, HR=0.193). This beneficial effect was seen in AML/myelodysplastic syndrome and also in chronic myeloid leukemia. In myeloid disease, missing KIR ligands also improved 5-year OS (P=0.034, HR=0.430) and disease-free survival (DFS) (P=0.024, HR=0.445). Meanwhile, the presence of donor-activating KIR2DS3 gene was associated with increased relapse risk (P=0.003, HR=5.046), decreased OS (P=0.004, HR=3.181) and DFS (P=0.003, HR=2.919) in myeloid disease. No effect was seen in patients with lymphoid disease. Our study indicated that, in unrelated HSCT for myeloid leukemia, missing KIR ligands in recipients offered a lower relapse risk and a long-term survival advantage. The presence of KIR2DS3 in the donor was an important risk factor for myeloid leukemia.
- Subjects
KILLER cells; STEM cell transplantation; ACUTE myeloid leukemia; LIGANDS (Biochemistry); GRAFT versus host disease; IMMUNOGLOBULIN G; HEMATOPOIETIC stem cells; GENETICS
- Publication
Bone Marrow Transplantation, 2010, Vol 45, Issue 10, p1514
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2010.3