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- Title
Influence of inactivated feline retrovirus on feline alpha interferon and immunoglobulin production.
- Authors
Yasuda, M.; Good, R. A.; Day, Noorbibi K.
- Abstract
The effect of ultraviolet-inactivated feline leukaemia virus (UV-FeLV) on the development of feline immunoglobulin-secreting cells (ISC) was investigated using a reverse haemolytic plaque assay. Low concentrations of UV-FeLV at 2× 10-4 to 2.0 μg/ml stimulated the production of ISC. By contrast, the same concentration of UV-FcLV suppressed the development of pokeweed mitogen (PWM)-drivcn ISC. Maximum suppression of ISC occurred al 50/J g/ml of UV-FeLV. The generation of an interferon resistant to acid, heat and sodium dodecyt sulphate (SDS) in the media of lymphocyte cultures incubated with PWM was also significantly suppressed in the presence of 0'2 /ig/ ml of UV-FeLV. These findings suggest that non-infectious viral particles appear to modify feline immunoglobulin and interferon-secreting systems.
- Subjects
HEMOLYTIC plaque technique; HEMOLYSIS &; hemolysins; PLAQUE assay technique; ANTIVIRAL agents; GLYCOPROTEINS; RETROVIRUS diseases
- Publication
Clinical & Experimental Immunology, 1987, Vol 69, Issue 2, p240
- ISSN
0009-9104
- Publication type
Article