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- Title
Fatal acute hepatic failure secondary to thrombotic portal venopathy after commencing abemaciclib and fulvestrant treatment for advanced breast carcinoma: a unique autopsy finding.
- Authors
Haynes, Harry R; Mohan, Vivek; Mozayani, Behrang; Gallagher, Patrick
- Abstract
We present an autopsy case of hepatic thrombotic portal venopathy resulting in decompensated liver failure and death which occurred rapidly after commencing abemaciclib and fulvestrant chemotherapy for advanced invasive lobular carcinoma of the breast. The diagnosis was confirmed histologically. This is the first reported case of such a finding. We suggest that further cases displaying this previously unpublished pattern are collated in order that we may begin to investigate the underlying etiological mediators.
- Subjects
THROMBOSIS diagnosis; THROMBOSIS complications; THERAPEUTIC use of proteins; THERAPEUTIC use of antineoplastic agents; THROMBOSIS; LOBULAR carcinoma; LIVER blood-vessels; CANCER invasiveness; AUTOPSY; LIVER; TREATMENT effectiveness; PORTAL vein; HISTOLOGICAL techniques; ACUTE diseases; LIVER failure; BREAST tumors; DISEASE complications
- Publication
Breast Journal, 2021, Vol 27, Issue 7, p612
- ISSN
1075-122X
- Publication type
Article
- DOI
10.1111/tbj.14238