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- Title
Association of the α-adducin polymorphism with blood pressure and risk of myocardial infarction.
- Authors
Psaty, B M; Doggen, C; Vos, H L; Vandenbroucke, J P; Rosendaal, F R
- Abstract
Genetic variation in adducin, a protein associated with the inner leaflet of the plasma membrane, may be in part responsible for salt-sensitive hypertension. In the Netherlands, 560 men who survived a myocardial infarction and 646 men who had undergone an orthopaedic intervention participated in a case-control study. In men in this study, the α-adducin polymorphism was not associated with the risk of myocardial infarction either among those with or among those without a clinical history of hypertension. In a cross-sectional analysis of blood pressure data from the controls, the α-adducin polymorphism was associated neither with self-reported hypertension (OR = 0.78, 95% CI = 0.51-1.19) nor with mean levels of systolic or diastolic blood pressure. Additional studies in other populations are needed to assess the contribution of α-adducin to high blood pressure and cardiovascular risk.
- Subjects
HYPERTENSION; BLOOD proteins; MYOCARDIAL infarction
- Publication
Journal of Human Hypertension, 2000, Vol 14, Issue 2, p95
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/sj.jhh.1000943