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- Title
Case report: Significant relief of linezolid-induced peripheral neuropathy in a pre-XDR-TB case after acupuncture treatment.
- Authors
Yuping Mo; Zhu Zhu; Jie Tan; Zhilin Liang; Jiahui Wu; Xingcheng Chen; Ming Hu; Peize Zhang; Guofang Deng; Liang Fu
- Abstract
The revisedWHO guidelines onmultidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) include linezolid in the core drug group. Common adverse events of prolonged linezolid use are bonemarrow suppression and peripheral neuropathy (PN). Availablemeasures against linezolid-induced PN (LIPN) often have insignificant effects, leading to linezolid discontinuation and a decline in the success rate of MDR/RR-TB treatment. Acupuncture treatment is a symptomatic treatment measure from traditional Chinese medicine (TCM) to relieve pain with overall very lowevidence and has never been reported in LIPN. The pilot use of acupuncture in a pre-extensively drug-resistant (XDR)-TB (a more severe form of MDR/RR-TB) patient exhibited significant improvements in LIPN and thus maintained linezolid in the regimen for a longer period.
- Subjects
PERIPHERAL neuropathy; TUBERCULOUS meningitis; ACUPUNCTURE; CHINESE medicine; LINEZOLID; MULTIDRUG-resistant tuberculosis
- Publication
Frontiers in Neurology, 2022, Vol 13, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2022.985499