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- Title
Diagnostic Importance of Clinic-Pathologic Features and p16, CD34, MDM2 Expression in Differential Diagnosis of Tumors.
- Authors
Deval, Pankaj; Agrawal, Kaveri
- Abstract
Background: The large majority of soft tissue tumors are benign. Malignant mesenchymal neoplasm amount to less than 1% of the overall human burden of malignant tumors but they are life threatening and may pose a significant diagnostic and therapeutic challenge since there are more than 50 histological subtypes of STS, which are often associated with unique clinical, prognostic and therapeutic features. Methods: The study was undertaken in department of Pathology, King George's Medical University, Lucknow. The Study Design was Retrospective and prospective study carried over a period of two year from September 2018 to august 2020 including 70 cases. Results. Most common diagnosis of malignant cases was Synovial saroma (21.4%) followed by Leiomyosarcoma (19.0%) and Undifferentiated pleomorphic sarcoma & Fibromyxoid sarcoma (11.9% each). Less common diagnosis were Ewing's sarcoma, Liposarcoma and Rhabdomyosarcoma (9.5% each), 1 (2.4%) case each was diagnosed as Chondrosarcoma, MPNST and Myxoid liposarcoma. Conclusions: Genetic alterations involving the 12q13-15 chromosomal region are common in musculoskeletal sarcomas, and many bone and soft-tissue malignant tumors showed amplification of various genes located in this region.
- Subjects
LUCKNOW (India); EWING'S sarcoma; SOFT tissue tumors; TUMOR diagnosis; BENIGN tumors; SYNOVIOMA; LIPOSARCOMA; DIFFERENTIAL diagnosis
- Publication
Indian Journal of Public Health Research & Development, 2024, Vol 15, Issue 1, p84
- ISSN
0976-0245
- Publication type
Case Study
- DOI
10.37506/drt8cs80