Found: 68
Select item for more details and to access through your institution.
Tankyrase-targeted therapeutics: expanding opportunities in the PARP family.
- Published in:
- Nature Reviews Drug Discovery, 2012, v. 11, n. 12, p. 923, doi. 10.1038/nrd3868
- By:
- Publication type:
- Article
Utilizing RNA interference to enhance cancer drug discovery.
- Published in:
- 2007
- By:
- Publication type:
- journal article
Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells.
- Published in:
- EMBO Molecular Medicine, 2012, v. 4, n. 10, p. 1087, doi. 10.1002/emmm.201201250
- By:
- Publication type:
- Article
Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition.
- Published in:
- EMBO Molecular Medicine, 2010, v. 2, n. 4, p. 130, doi. 10.1002/emmm.201000068
- By:
- Publication type:
- Article
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors.
- Published in:
- EMBO Molecular Medicine, 2009, v. 1, n. 6/7, p. 315, doi. 10.1002/emmm.200900041
- By:
- Publication type:
- Article
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2.
- Published in:
- EMBO Molecular Medicine, 2009, v. 1, n. 6/7, p. 323, doi. 10.1002/emmm.200900040
- By:
- Publication type:
- Article
Three-dimensional modelling identifies novel genetic dependencies associated with breast cancer progression in the isogenic MCF10 model.
- Published in:
- Journal of Pathology, 2016, v. 240, n. 3, p. 315, doi. 10.1002/path.4778
- By:
- Publication type:
- Article
Overexpression of MYB drives proliferation of CYLD-defective cylindroma cells.
- Published in:
- Journal of Pathology, 2016, v. 239, n. 2, p. 197, doi. 10.1002/path.4717
- By:
- Publication type:
- Article
Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours.
- Published in:
- Journal of Pathology, 2015, v. 236, n. 2, p. 186, doi. 10.1002/path.4517
- By:
- Publication type:
- Article
Structural basis for recruitment of BRCA2 by PALB2.
- Published in:
- EMBO Reports, 2009, v. 10, n. 9, p. 990, doi. 10.1038/embor.2009.126
- By:
- Publication type:
- Article
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.
- Published in:
- EMBO Reports, 2006, v. 7, n. 2, p. 219, doi. 10.1038/sj.embor.7400587
- By:
- Publication type:
- Article
DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells.
- Published in:
- EMBO Reports, 2004, v. 5, n. 10, p. 989, doi. 10.1038/sj.embor.7400255
- By:
- Publication type:
- Article
Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency.
- Published in:
- Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02770-2
- By:
- Publication type:
- Article
The Mutational Concordance of Fixed Formalin Paraffin Embedded and Fresh Frozen Gastro-Oesophageal Tumours Using Whole Exome Sequencing.
- Published in:
- Journal of Clinical Medicine, 2021, v. 10, n. 2, p. 215, doi. 10.3390/jcm10020215
- By:
- Publication type:
- Article
Statistical Modeling of Interlocus Interactions in a Complex Disease: Rejection of the...
- Published in:
- Genetics, 2001, v. 158, n. 1, p. 357, doi. 10.1093/genetics/158.1.357
- By:
- Publication type:
- Article
Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress.
- Published in:
- Nucleic Acids Research, 2014, v. 42, n. 10, p. 6270, doi. 10.1093/nar/gku299
- By:
- Publication type:
- Article
Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.
- Published in:
- Nucleic Acids Research, 2012, v. 40, n. 15, p. 7190, doi. 10.1093/nar/gks389
- By:
- Publication type:
- Article
Targeting p90 Ribosomal S6 Kinase Eliminates Tumor-Initiating Cells by Inactivating Y-Box Binding Protein-1 in Triple-Negative Breast Cancers.
- Published in:
- Stem Cells, 2012, v. 30, n. 7, p. 1338, doi. 10.1002/stem.1128
- By:
- Publication type:
- Article
Mechanisms of resistance to therapies targeting BRCA-mutant cancers.
- Published in:
- Nature Medicine, 2013, v. 19, n. 11, p. 1381, doi. 10.1038/nm.3369
- By:
- Publication type:
- Article
Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast.
- Published in:
- Journal of Pathology, 2014, v. 232, n. 5, p. 553, doi. 10.1002/path.4325
- By:
- Publication type:
- Article
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor.
- Published in:
- Journal of Pathology, 2013, v. 229, n. 3, p. 422, doi. 10.1002/path.4140
- By:
- Publication type:
- Article
Functional characterization of EMSY gene amplification in human cancers.
- Published in:
- Journal of Pathology, 2011, v. 225, n. 1, p. 29, doi. 10.1002/path.2944
- By:
- Publication type:
- Article
Transition from cylindroma to spiradenoma in CYLD-defective tumours is associated with reduced DKK2 expression.
- Published in:
- Journal of Pathology, 2011, v. 224, n. 3, p. 309, doi. 10.1002/path.2896
- By:
- Publication type:
- Article
Genomic instability and the selection of treatments for cancer.
- Published in:
- Journal of Pathology, 2010, v. 220, n. 2, p. 281, doi. 10.1002/path.2631
- By:
- Publication type:
- Article
Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation.
- Published in:
- Journal of Pathology, 2009, v. 219, n. 3, p. 306, doi. 10.1002/path.2599
- By:
- Publication type:
- Article
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
- Published in:
- Nature Genetics, 2012, v. 44, n. 11, p. 1182, doi. 10.1038/ng.2417
- By:
- Publication type:
- Article
RAD51, BRCA2 and DNA repair: a partial resolution.
- Published in:
- Nature Structural & Molecular Biology, 2007, v. 14, n. 6, p. 461, doi. 10.1038/nsmb0607-461
- By:
- Publication type:
- Article
A Genetic Screen Using the PiggyBac Transposon in Haploid Cells Identifies <i>Parp1</i> as a Mediator of Olaparib Toxicity.
- Published in:
- PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061520
- By:
- Publication type:
- Article
NLK Is a Novel Therapeutic Target for PTEN Deficient Tumour Cells.
- Published in:
- PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047249
- By:
- Publication type:
- Article
A Modified Method for Whole Exome Resequencing from Minimal Amounts of Starting DNA.
- Published in:
- PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0032617
- By:
- Publication type:
- Article
Comprehensive Genomic Analysis of a BRCA2 Deficient Human Pancreatic Cancer.
- Published in:
- PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021639
- By:
- Publication type:
- Article
Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer Targets.
- Published in:
- PLoS ONE, 2009, v. 4, n. 4, p. 1, doi. 10.1371/journal.pone.0005120
- By:
- Publication type:
- Article
Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.
- Published in:
- PLoS Genetics, 2021, v. 17, n. 2, p. 1, doi. 10.1371/journal.pgen.1009354
- By:
- Publication type:
- Article
Structural basis for recruitment of BRCA2 by PALB2.
- Published in:
- EMBO Reports, 2017, v. 18, n. 7, p. 1264, doi. 10.15252/embr.201744508
- By:
- Publication type:
- Article
Quantitative Assessment and Prognostic Associations of the Immune Landscape in Ovarian Clear Cell Carcinoma.
- Published in:
- Cancers, 2021, v. 13, n. 15, p. 3854, doi. 10.3390/cancers13153854
- By:
- Publication type:
- Article
A Machine-Learning Tool Concurrently Models Single Omics and Phenome Data for Functional Subtyping and Personalized Cancer Medicine.
- Published in:
- Cancers, 2020, v. 12, n. 10, p. 2811, doi. 10.3390/cancers12102811
- By:
- Publication type:
- Article
Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.
- Published in:
- Molecular Oncology, 2024, v. 18, n. 2, p. 369, doi. 10.1002/1878-0261.13537
- By:
- Publication type:
- Article
Resistance to DNA repair inhibitors in cancer.
- Published in:
- Molecular Oncology, 2022, v. 16, n. 21, p. 3811, doi. 10.1002/1878-0261.13224
- By:
- Publication type:
- Article
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
- Published in:
- EMBO Journal, 2012, v. 31, n. 5, p. 1160, doi. 10.1038/emboj.2011.490
- By:
- Publication type:
- Article
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
- Published in:
- EMBO Journal, 2008, v. 27, n. 9, p. 1368, doi. 10.1038/emboj.2008.61
- By:
- Publication type:
- Article
Resistance to therapy caused by intragenic deletion in BRCA2.
- Published in:
- Nature, 2008, v. 451, n. 7182, p. 1111, doi. 10.1038/nature06548
- By:
- Publication type:
- Article
CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
- Published in:
- Carcinogenesis, 2009, v. 30, n. 10, p. 1696, doi. 10.1093/carcin/bgp187
- By:
- Publication type:
- Article
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.
- Published in:
- Nature Communications, 2016, v. 7, n. 12, p. 13837, doi. 10.1038/ncomms13837
- By:
- Publication type:
- Article
High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing.
- Published in:
- Genome Biology, 2011, v. 12, n. 10, p. 1, doi. 10.1186/gb-2011-12-10-r104
- By:
- Publication type:
- Article
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
- Published in:
- British Journal of Cancer, 2017, v. 117, n. 1, p. 113, doi. 10.1038/bjc.2017.133
- By:
- Publication type:
- Article
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Comparing Jacques Delors and Jacques Santer as Presidents of the European Commission: Skill in Supranational Context.
- Published in:
- Politics & Policy, 2002, v. 30, n. 2, p. 324, doi. 10.1111/j.1747-1346.2002.tb00125.x
- By:
- Publication type:
- Article
Biology-driven cancer drug development:back to the future.
- Published in:
- BMC Biology, 2010, v. 8, p. 38, doi. 10.1186/1741-7007-8-38
- By:
- Publication type:
- Article
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
- Published in:
- Nature, 2005, v. 434, n. 7035, p. 917, doi. 10.1038/nature03445
- By:
- Publication type:
- Article
PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors.
- Published in:
- Science Translational Medicine, 2010, v. 2, n. 53, p. 1, doi. 10.1126/scitranslmed.3001538
- By:
- Publication type:
- Article