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- Title
Actin' up: Herpesvirus Interactions with Rho GTPase Signaling.
- Authors
Van den Broeke, Céline; Favoreel, Herman W.
- Abstract
Herpes viruses constitute a very large and diverse family of DNA viruses, which can generally be subdivided in alpha-, beta- and gamma herpes virus subfamilies. Increasing evidence indicates that many herpes viruses interact with cytoskeleton-regulating Rho GTPase signaling pathways during different phases of their replication cycle. Because of the large differences between herpes virus subfamilies, the molecular mechanisms and specific consequences of individual herpes virus interactions with Rho GTPase signaling may differ. However, some evolutionary distinct but similar general effects on Rho GTPase signaling and the cytoskeleton have also been reported. Examples of these include Rho GTPase-mediated nuclear translocation of virus during entry in a host cell and Rho GTPase-mediated viral cell-to-cell spread during later stages of infection. The current review gives an overview of both general and individual interactions of herpes viruses with Rho GTPase signaling.
- Subjects
HERPESVIRUSES; RHO GTPases; ACTIN; CYTOSKELETON; CHROMOSOMAL translocation
- Publication
Viruses (1999-4915), 2011, Vol 3, Issue 4, p278
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v3040278