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- Title
HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear.
- Authors
D'Orso, Iván; Frankel, Alan D.
- Abstract
HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature 2010, 465, 747-751.) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.
- Subjects
HIV; VIRAL proteins; THERAPEUTIC use of proteins; MICROBIAL polymers; SEXUALLY transmitted diseases
- Publication
Viruses (1999-4915), 2010, Vol 2, Issue 10, p2226
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v2102226