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- Title
HIV-1 Entry, Inhibitors, and Resistance.
- Authors
Lobritz, Michael A.; Ratcliff, Annette N.; Arts, Eric J.
- Abstract
Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical use. Several potential mechanisms have been proposed: tropism switching (utilization of CXCR4 instead of CCR5 for entry), increased affinity for the coreceptor, increased rate of virus entry into host cells, and utilization of inhibitor-bound receptor for entry. In this review we will address the development of attachment, fusion, and coreceptor entry inhibitors and explore recent studies describing potential mechanisms of resistance.
- Subjects
THERAPEUTICS; HIV infections; ANTIRETROVIRAL agents; VIRAL disease prevention; CELL receptors; LIFE expectancy; MEMBRANE fusion; EFFECT of drugs on viruses; INFECTION; NATURAL immunity; PATIENTS
- Publication
Viruses (1999-4915), 2010, Vol 2, Issue 5, p1069
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v2051069