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- Title
Investigation of the Spatial Structure of Flufenamic Acid in Supercritical Carbon Dioxide Media via 2D NOESY.
- Authors
Khodov, Ilya A.; Belov, Konstantin V.; Krestyaninov, Michael A.; Dyshin, Alexey A.; Kiselev, Michael G.
- Abstract
The search for new forms of already known drug compounds is an urgent problem of high relevance as more potent drugs with fewer side effects are needed. The trifluoromethyl group in flufenamic acid renders its chemical structure differently from other fenamates. This modification is responsible for a large number of conformational polymorphs. Therefore, flufenamic acid is a promising structural modification of well-known drug molecules. An effective approach in this field is micronization, employing "green" supercritical fluid technologies. This research raises some key questions to be answered on how to control polymorphic forms during the micronization of drug compounds. The results presented in this work demonstrate the ability of two-dimensional nuclear Overhauser effect spectroscopy to determine conformational preferences of small molecular weight drug compounds in solutions and fluids, which can be used to predict the polymorphic form during the micronization. Quantitative analysis was carried out to identify the conformational preferences of flufenamic acid molecules in dimethyl sulfoxide-d6 medium at 25 °C and 0.1 MPa, and in mixed solvent medium containing supercritical carbon dioxide at 45 °C and 9 MPa. The data presented allows predictions of the flufenamic acid conformational preferences of poorly soluble drug compounds to obtain new micronized forms.
- Subjects
OVERHAUSER effect (Nuclear physics); SUPERCRITICAL carbon dioxide; SUPERCRITICAL fluids; MOLECULAR weights; CHEMICAL structure
- Publication
Materials (1996-1944), 2023, Vol 16, Issue 4, p1524
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma16041524