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- Title
Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO.
- Authors
Himmels, Sarah-Felicitas; Sartori, Alessandro A.
- Abstract
DNA double-strand breaks (DSBs) are one of the most detrimental lesions, as their incorrect or incomplete repair can lead to genomic instability, a hallmark of cancer. Cells have evolved two major competing DSB repair mechanisms: Homologous recombination (HR) and non-homologous end joining (NHEJ). HR is initiated by DNA-end resection, an evolutionarily conserved process that generates stretches of singlestranded DNA tails that are no longer substrates for religation by the NHEJ machinery. Ubiquitylation and sumoylation, the covalent attachment of ubiquitin and SUMO moieties to target proteins, play multifaceted roles in DNA damage signaling and have been shown to regulate HR and NHEJ, thus ensuring appropriate DSB repair. Here, we give a comprehensive overview about the current knowledge of how ubiquitylation and sumoylation control DSB repair by modulating the DNA-end resection machinery.
- Subjects
UBIQUITIN genetics; DNA damage; GENETIC recombination
- Publication
Frontiers in Genetics, 2016, p1
- ISSN
1664-8021
- Publication type
Article
- DOI
10.3389/fgene.2016.00152