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- Title
Inhibition of BCR/ABL Protein Expression by miR-203 Sensitizes for Imatinib Mesylate.
- Authors
Li, Yajuan; Yuan, Ying; Tao, Kun; Wang, Xin; Xiao, Qing; Huang, Zhenglan; Zhong, Liang; Cao, Weixi; Wen, Jianping; Feng, Wenli
- Abstract
Selective inhibition of BCR/ABL expression by RNA interference has been demonstrated as an effective strategy in CML treatment and a reversal to imatinib resistance. microRNAs (miRNAs) are small regulatory RNAs involved in post-transcriptional gene regulation. miR-203 is supposed to directly regulate ABL and BCR/ABL expression, however, the role of miR-203 in imatinib-resistant cells is not clear. Here, we report that overexpression of miR-203 in BaF3-BCR/ABL cells with T315I mutant inhibited cell growth and colony formation ability. Furthermore, miR-203 increased sensitivity to imatinib in BaF3-BCR/ABLT315I cells, thereby antagonizing the main mechanism of resistance to imatinib.
- Subjects
PROTEIN-tyrosine kinase inhibitors; GENE expression; MICRORNA; METHANESULFONATES; IMATINIB; RNA interference; DRUG resistance
- Publication
PLoS ONE, 2013, Vol 8, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0061858