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- Title
The Relationship Between Physical Activity and Risk of Atrial Fibrillation-A Systematic Review and Meta-Analysis.
- Authors
Nielsen, Jens Rokkedal; Wachtell, Kristian; Abdulla, Jawdat
- Abstract
Aim: The aim of this systematic literature review and meta-analyses was to explore the relationship between physical activity and risk of new-onset atrial fibrillation (AF) or flutter (AFlu). Results: The search revealed 10 published studies that were eligible for three different meta-analyses. A meta-analysis of six case-control studies showed that risk of AF increased more than 5-fold in athletes compared to non-athletic controls, OR=5.3 [(3.6, 7.9; 95% confidence interval (CI)], p<0.0001. A second meta-analysis of three case-control studies showed a significantly higher prevalence of athletes among AF populations compared to their healthy controls, OR=4.7 (3.1-6.9; 95% CI), p<0.0001. A third meta-analysis of three prospective large-scale long-term studies showed that moderate/high habitual physical activity was associated with significantly reduced risk of AF compared with none or very low intensity physical activity OR=0.89(0.83, 0.96; 95% CI), p=002. Conclusions: Long-term vigorous physical training or lack of physical activity both are associated with increased risk of AF, while habitual moderate physical activity may be associated with reduced risk. Further large-scale prospective randomized controlled studies particularly in athletes are needed to further confirm these findings.
- Subjects
ATRIAL fibrillation; PHYSICAL activity; META-analysis; CONFIDENCE intervals; PHYSICAL training &; conditioning; ATHLETES; CONTROL groups; RANDOMIZED controlled trials
- Publication
JAFIB: Journal of Atrial Fibrillation, 2013, Vol 5, Issue 5, p20
- ISSN
1941-6911
- Publication type
Article