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- Title
Spatial Relational Memory Requires Hippocampal Adult Neurogenesis.
- Authors
Dupret, David; Revest, Jean-Michel; Koehl, Muriel; Ichas, François; De Giorgi, Francesca; Costet, Pierre; Abrous, Djoher Nora; Piazza, Pier Vincenzo
- Abstract
The dentate gyrus of the hippocampus is one of the few regions of the mammalian brain where new neurons are generated throughout adulthood. This adult neurogenesis has been proposed as a novel mechanism that mediates spatial memory. However, data showing a causal relationship between neurogenesis and spatial memory are controversial. Here, we developed an inducible transgenic strategy allowing specific ablation of adult-born hippocampal neurons. This resulted in an impairment of spatial relational memory, which supports a capacity for flexible, inferential memory expression. In contrast, less complex forms of spatial knowledge were unaltered. These findings demonstrate that adult-born neurons are necessary for complex forms of hippocampus-mediated learning.
- Subjects
DENTATE gyrus; HIPPOCAMPUS (Brain); NEUROTROPHIC functions; NEURAL development; NEURONS; NEURAL circuitry; AGE factors in memory; DEVELOPMENTAL neurobiology; NEUROGENETICS
- Publication
PLoS ONE, 2008, Vol 3, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0001959