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- Title
Immunostimulant activity of Bergenia Extracts.
- Authors
Tumova, Lenka; Endrychová, Helena; Vokurková, Doris
- Abstract
Background: Bergenia species contain various therapeutically important compounds such as phenolic compounds-arbutin, bergenin, tannins, gallic acid, flavonoids, minerals, and many others. Bergenia plants show antibacterial, antiviral, anticancer, antidiabetic, diuretic and immunostimulant activities. Materials and Methods: Bergenia leaf extracts from Bergenia crassifolia, Bergenia ciliata, and Bergenia x ornata on lymphocyte activation using flow cytometry method were investigated. Their activation was then monitored with the help of the increasing fluorescence intensity. Results: By activating of cells, there has been an increase in the amount of the established antibodies. Bergenia extracts significantly stimulated the expression of CD69 on lymphocytes in the final concentration of 3.13 and 6.25 mg/ml. The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ. Conclusion: The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ.
- Subjects
SAXIFRAGACEAE; THERAPEUTIC use of plant extracts; IMMUNOLOGICAL adjuvants; PLANT phenols; FLAVONOIDS
- Publication
Pharmacognosy Magazine, 2018, Vol 14, Issue 56, p328
- ISSN
0973-1296
- Publication type
Article
- DOI
10.4103/pm.pm_423_17