We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Catalyst-Free Sulfonylation of 2-Methoxyphenols: Facile One-Pot Synthesis of (Arylsulfonyl)catechols in Aqueous Media.
- Authors
Taneja, Neha; Peddinti, Rama Krishna
- Abstract
A new water-assisted carbon-sulfur bond-formation strategy is described for direct access to highly valuable (arylsulfonyl) catechols. This scalable transformation is remarkable, as a tandem dearomatization/sulfonylation and hydroxylation process enabled the title compounds to be formed in one pot under catalyst-free conditions. Mechanistic studies revealed that water plays a key role in the synthesis of the catechols. The sulfonylation operates under very mild conditions, shows a broad substrate scope, gives high conversions, and can be carried out on a gram scale. Thus, this method represents a green, efficient method for carbon-sulfur bond formation. The aryl sulfones were also further transformed into molecules that are important for drug discovery.
- Subjects
PHENOLS; CATECHOL; AQUEOUS solutions; SULFUR bonding; DRUG development
- Publication
European Journal of Organic Chemistry, 2017, Vol 2017, Issue 35, p5306
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201701038