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- Title
DHCR24 in Tumor Diagnosis and Treatment: A Comprehensive Review.
- Authors
Fu, Xin; Wang, Zhaosong
- Abstract
As an important nutrient in the human body, cholesterol can not only provide structural components for the body's cells, but also can be transformed into a variety of active substances to regulate cell signaling pathways. As an important cholesterol synthase, DHCR24 participates in important regulatory processes in the body. The application of DHCR24 in tumor clinical diagnosis and treatment also attracts much attention. This article reviews the structure and regulatory characteristics of DHCR24, and the research of DHCR24 on tumor progression. We summarize the possible mechanisms of DHCR24 promoting tumor progression through reactive oxygen species (ROS), p53, Ras and PI3K-AKT pathways. Through our review, we hope to provide more research ideas and reference value for the application of DHCR24 in tumor prevention and treatment.
- Subjects
TUMOR diagnosis; TUMOR treatment; REACTIVE oxygen species; RAS oncogenes; CANCER invasiveness; CELL communication
- Publication
Technology in Cancer Research & Treatment, 2024, p1
- ISSN
1533-0346
- Publication type
Article
- DOI
10.1177/15330338241259780