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- Title
Nonantimicrobial Agents in the Prevention and Treatment of Traveler's Diarrhea.
- Authors
Ericsson, Charles D.
- Abstract
Among the nonantimicrobial agents that are available and useful for the prevention of traveler's diarrhea are bismuth subsalicylate-containing preparations, which can provide a rate of protection of up to 65% when taken 4 times daily. In one study, the probiotic Lactobacillus GG was found to provide 49% protection against traveler's diarrhea, but results with this agent and other probiotics have been highly variable and geographically inconsistent. Tannin albuminate plus ethacridine lactate provided 36% protection, but it is not widely available. Among the nonantimicrobial agents that are available and useful for the treatment of traveler's diarrhea are bismuth subsalicylate-containing preparations, which reduce the passage of loose stools by 16%-18%. The antisecretory and antimotility agent loperamide reduces the passage of loose stools by ∼50% and has been especially useful, in combination with antimicrobial agents, in reducing the total duration of posttreatment diarrhea to a matter of hours.
- Subjects
ANTIDIARRHEALS; DIARRHEA; TRAVEL hygiene; GASTROINTESTINAL agents; ANTI-infective agents; BISMUTH; COMBINATION drug therapy; THERAPEUTICS
- Publication
Clinical Infectious Diseases, 2005, Vol 41, pS557
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/432952