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- Title
APOLIPOPROTEINA E ŞI PROGRESIA NEFROPATIEI LA PACIENŢII DIA BETICI.
- Authors
Moldovan, Silviu Daniel; Popeţiu, Romana Olivia; Amza, Oana Lucia; Puşchiţă, Maria
- Abstract
Apolipoprotein (Apo) E plasma is a key factor of lipid metabolism. It is a surface component of triglycerides- rich lipoproteins, low-density lipoproteins (VLDL), chylomicron remnants and high-density lipoproteins (HDL). Most of the circulating ApoE is of hepatic origin, but can also be synthesized in the spleen, kidneys, lungs, muscle and central nervous system (6). The biological activity of ApoE depends on the polymorphism of the gene. ApoE is located on the long arm of chromosome 19, described as 3 alleles (ε2, ε3 and Ε4), which codifies 3 isoforms of ApoE: ε2, Ε3 and ε4 respectively. The clear, detailed definition of ApoE function in the 3 target locations - the hypothalamus, adipose tissue and plasma - can lead to an effective screening method based on the determination of the plasma lipid profile, ApoE becoming a readily detectable marker of metabolic disorder (11,12).
- Subjects
LOW density lipoproteins; BLOOD lipids; LIPID metabolism; CENTRAL nervous system; METABOLIC disorders; PLANT chromosomes; FACIOSCAPULOHUMERAL muscular dystrophy
- Publication
Romanian Medical Journal, 2019, Vol 66, Issue 3, p229
- ISSN
1220-5478
- Publication type
Article
- DOI
10.37897/rmj.2019.3.9