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- Title
Synthesis and characterization of novel bis(pyridine-2(1H)-thiones) and their bis(2-methylsulfanylpyridines) incorporating 2,6-dibromophenoxy moiety.
- Authors
Sanad, Sherif M.H.; Abdel-Fattah, Azza M.; Attaby, Fawzy A.; Elneairy, Mohamed A.A.
- Abstract
The novel 1,4-bis(2,6-dibromo-4-formylphenoxy)butane (3), prepared from 3,5-dibromobenzaldehyde (1), reacted with different hydrazines 4a–4d and active methylene containing compounds 9a–9d to give the corresponding bis(hydrazones) 5a–5d and bis(cinnamonitriles) 11a–11d, respectively. Both bis(2-cyanoacetic acid hydrazide) derivative 5d and bis(thioacrylamide) derivative 11a were taken as synthetic precursors for the synthesis of the target molecules bis(pyridine-2(1H)-thione) derivative 10 and 13a–13c and their bis(2-methylsulfanylpyridine) derivative 14 and 17a–17c. Another synthetic route was designed to prepare the target molecules 14 and 17a–17c in a better yield using pyridine-2(1H)-thione) derivative 15 and 19a–19c. Characterization of the newly prepared compounds via elemental analyses and spectral data are established.
- Subjects
PYRIDINE synthesis; PYRIDINE derivatives; FUNCTIONAL groups; BUTANE; BENZALDEHYDE; THIONES; HYDRAZINES; CHEMICAL precursors
- Publication
Canadian Journal of Chemistry, 2019, Vol 97, Issue 1, p53
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2017-0721