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- Title
Michael addition at neutral pH: a facile synthesis of 1,3-dinitroalkanes.
- Authors
Bora, Porag; Bora, Pranjal P.; Wahlang, Barisha; Bez, Ghanashyam
- Abstract
Base-catalyzed Michael addition of nitroalkane to conjugated nitroalkene suffers serious practical difficulties due to the formation of oligomeric byproduct. Given its importance for synthesis of pharmacologically relevant organic compounds, a scalable synthesis of 1,3-dinitroalkane is developed by addition of nitroalkane to nitroalkene in aqueous phosphate buffer at pH 7.0 with no added traditional base catalyst.
- Subjects
NITROALKANES; MICHAEL reaction; ORGANIC synthesis; PHOSPHATES; STEREOSELECTIVE reactions
- Publication
Canadian Journal of Chemistry, 2017, Vol 95, Issue 12, p1261
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2017-0257