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- Title
Microvascular density analysis and histological parameters of oral cancer progression.
- Authors
Batistella, Elis Angela; Miguel, Andressa Fernanda Paza; Nascimento, Nicole Lonni; Horta, Martinho Campolina Rebello; Vieira, Daniella Serafin Couto; Rivero, Elena Riet Correa
- Abstract
Objectives: This study aimed to investigate the role of blood and lymphatic microvascular density in the progression of oral squamous cell carcinoma (OSCC). Materials and Methods: The sample was composed of 54 cases of OSCC. The immunoexpression to anti‐alpha‐smooth muscle actin (α‐SMA) and to anti‐endoglin (CD105) was used to determine the microvessel density (MVD); anti‐podoplanin (D2‐40) was used to assess the lymphatic vessel density (LVD); vascular endothelial growth factor (VEGF) was evaluated in malignant cells. The histological differentiation, the worst pattern of invasion (WPOI), tumour thickness and tumour budding (TB) intensity were assessed using haematoxylin–eosin and anti‐pan‐cytokeratin (AE1/AE3). Patients' age and sex, TNM classification and follow‐up time were collected from the medical records. Results: MVD markers presented a similar pattern of expression in blood vessels. However, only α‐SMA + MVD was significantly higher among women and in tumours ≤4 cm. LVD was lower in tumours with lymph node metastasis. Regarding the histological parameters, high TB intensity was associated with histological differentiation, advanced clinical stage, greater tumour thickness and reduced disease‐free survival. No difference was found in VEGF. Conclusions: The decrease in OSCC LVD could be related to pathological node involvement, whereas high TB intensity could indicate OSCC progression and worse patient outcomes.
- Subjects
SQUAMOUS cell carcinoma; LYMPHATICS; VASCULAR endothelial growth factors; MOUTH tumors; RESEARCH funding; SEX distribution; GLYCOPROTEINS; TUMOR markers; CARDIOVASCULAR system physiology; HISTOLOGICAL techniques; DISEASE progression
- Publication
Oral Diseases, 2024, Vol 30, Issue 4, p2110
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.14694