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- Title
Alteration of T--Lymphocyte Subpopulations in Patients with Primary Renal Diseases and Systemic Lupus Erythematosus.
- Authors
Matsumoto, K.; Osakabe, K.; Ohi, H.; Yoshizawa, N.; Harada, M.; Hatano, M.
- Abstract
Forty-eight patients with a variety of primary renal diseases and systemic lupus erythematosus (SLE) were examined for the proportion of circulating T lymphocytes bearing receptors for IgM (Tμ cells) or IgG (Tγ cells). Although the control group showed strikingly similar mean values for both Tμ and Tγ cells, the whole group of patients with primary renal diseases and SLE showed a wide scatter of values. Sixteen patients with primary renal diseases and SLE had higher proportions of Tγ cells than the control group, whereas seven patients with chronic glomerulonephritis (CGN), membranoproliferative glomerulonephritis (MPGN), lipoid nephrosis (LN), and SLE showed very marked decrease in the proportions of Tγ cells in the peripheral blood. On the other hand, six out of the total group of patients had low proportions of Tμ cells in the peripheral blood. However, no consistent relationship between the proportion of Tμ and Tγ cells was found in our study. These findings indicate that there exists a heterogeneity of T-lymphocyte subpopulation distribution in some patients with primary renal diseases and SLE. The possible significance of these phenomena in the pathophysiology of renal diseases is discussed.
- Subjects
T cells; LYMPHOCYTE receptors; KIDNEY diseases; SYSTEMIC lupus erythematosus; AUTOIMMUNE diseases; BLOOD cells; ETIOLOGY of diseases
- Publication
Scandinavian Journal of Immunology, 1980, Vol 11, Issue 2, p187
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1980.tb00226.x